Epstein-barr virus infection induces lupus autoimmune

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Infection of adolescents can result in infectious mononucleosis, an acute serious condition characterized by massive lymphocytosis. Transmission of EBV mainly occurs through saliva but can rarely be spread through semen or blood, e. And despite intensive searching, the researchers found no evidence that other viral infections played a role. The findings "strongly suggest" that Epstein-Barr infection is "a cause and not a consequence of MS," study author Dr.

Alberto Ascherio of the Harvard T. Chan School of Public Health and colleagues reported in the journal Science. It's clearly not the only factor, considering that about 90 per cent of adults have antibodies showing they've had Epstein-Barr — while nearly one million people in the U.

Canada, meanwhile, has one of the highest rates of MS in the world. Figures from the MS Society of Canada suggest an estimated 90, Canadians are living with the disease, or one in every people. The virus appears to be "the initial trigger," Drs. William H. Robinson and Lawrence Steinman of Stanford University wrote in an editorial accompanying Thursday's study. In the study, published in the medical journal Nature Genetics, researchers looked at the genetic impact of several proteins in EBV.

They found that one of them—Epstein-Barr virus nuclear antigen 2 EBNA2 —interacts with half of the known genes that put someone with European ancestry at risk for lupus. Researchers looked at hundreds of other illnesses and discovered the same association with the other six linked to the virus.

People of other ancestries were not included in this analysis, but are not currently known to have a different risk profile for, at minimum, EBV. Most of us think of genetics as a fixed thing, but it's not that simple. Illness, environmental, and other factors can turn genes on or off. Think of a breaker box: turn one switch off, you lose power to an area of your house. Turn it on, things roar to life. The same is true when it comes to genes and their positive or negative effect on the body.

Many people are born with genetic predispositions to certain illnesses. That doesn't mean they'll develop those diseases, but it means that they could get them under the right circumstances. What this study demonstrates is that EBV appears to have the ability to switch on genes that cause your immune system to incorrectly target things that are safe.

That, plus a genetic predisposition to autoimmune disease, can lead to the illness be it multiple sclerosis, celiac, lupus, what have you. Meanwhile, someone without a genetic predisposition to any autoimmune diseases can contract EBV and have no problems with it. This is just the first study to demonstrate that EBV has the switching-on ability, and that means the case is far from closed.

Further research will need to confirm the link. However, this points to directions for such research, and some scientists are hailing it as a paradigm shift. In fact, this potentially groundbreaking study has had a swift impact on researchers. A multiple sclerosis study published in mentioned this study and the potential link between EBV and MS.

Researchers added that antiviral treatments for MS are being studied. Another study states: "Infection with Epstein-Barr virus EBV appears to be necessary for the development of multiple sclerosis. If the research is right and there is an association between EBV and autoimmunity, it could lead to more effective treatments for numerous diseases. Right now, there's no vaccine for EBV. The study findings may spur more research into a vaccine, since one wouldn't just stop the spread of mono, but could potentially prevent multiple life-long and debilitating diseases.

Chances are good that you'll come in contact with the Epstein-Barr virus at some point in your life. If any of these seven autoimmune diseases run in your family, it's possible that you have a genetic predisposition.